The final goal of neuroscience is to fully understand neural processes, their relations to mental processes and to cognitive, affective, and behavioral disorders. Computational modeling, although still in its infancy, already plays a central role in this endeavor. A review of different aspects of computational models that help to explain many features of neuropsychological syndromes and psychiatric disease is presented. Recent advances in computational modeling of epilepsy, cortical reorganization after lesions, Parkinson’s and Alzheimer diseases are reviewed. Some trends in computational models of brain functions are identified.

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Reference: Duch W, Computational Models of Dementia and Neurological Problems. Book chapter, Neuroinformatics, C.J. Crasto (Ed), "Methods in Molecular Biology" series (J. Walker, series ed.), Humana Press, Totowa, NJ, Chapter 17, pp. 307-336, 2007

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